Clinical Trials
BCNI Clinical Trials
See our short film which gives one Irish patient's experience on a clinical trial and gives an overview of clinical trials by Prof Michael O'Dwyer, Director of Blood Cancer Newtork Ireland
BCNI will carry out early phase (Phase I) clinical trials in cancer care centres in Galway, Cork and Dublin. Clinical trials are designed to develop and test new and improved ways to treat cancer in people; help prevent a return of cancer; and improve comfort and quality of life for people with cancer. Advances in treatments for blood cancers depend on clinical trials of new therapies or new combinations of therapies. BCNI trials will focus on novel targeted approaches, including immunotherapy.
Please see here for Patient information leaflet -Clinical trials
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Clinical trials are designed to develop and test new and improved therapies
New therapies are usually developed and tested in a laboratory. Then they are thoroughly tested in animals. If the early research (the preclinical trials) shows the therapy is safe and effective, a carefully planned and monitored clinical trial of the drug or treatment will then be conducted in people.
Advances in treatments for blood cancers depend on clinical trials of new therapies or new combinations of therapies.
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The BCNI will carry out early phase (phase I) clinical trials in cancer care centres in strategic geographical locations (Galway, Cork & Dublin) under a single unified structure.
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This will be led by University Hospital Galway, which has well established phase I trial expertise for blood cancers and phase I capability will be rapidly extended to the other centres (St James’s Hospital, Mercy University Hospital, Cork University Hospital, Beaumont hospital and the Mater hospital).
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The cohesive and national structure of the BCNI will make Ireland an attractive place for industry and clinical researchers to carry out their clinical trials. The main advantage of this is that it will provide Irish patients with easier access to novel experimental drugs and provide them with a very high level of care and attention.
ACTIVE CLINICAL TRIALS
Please see below for our clinical trials that are currently active and enrolling participants
Multiple Myeloma
Study Title |
Patient Population |
BCNI Sites Open for Enrollment |
ClinicalTrials.gov link for further study info |
Study Contacts |
|---|---|---|---|---|
| A Phase I Open-Label Dose Escalation Study to Determine the Efficacy, Safety and Pharmacokinetics of GMI-1271 as Adjunct to Standard of Care Chemotherapy for the Treatment of Multiple Myeloma | Relapsed/Refractory Multiple Myeloma |
Galway University Hospital Beaumont Hospital Cork University Hospital |
GMI1271-230 |
GUH: Jessica Walsh +353 (0)91 893314 Beaumont Hospital: Tara Kenny +353 (0)18 09 2080 Cork University Hospital: Contact:Debra O’Hare+353 (0)21 49 20051 |
Multiple Myeloma
Study Title |
Patient Population |
BCNI Sites Planned for involvement |
ClinicalTrials.gov link for further study info |
Study Contacts |
|---|---|---|---|---|
| Phase Ib study of weekly Cyclophosphamide-Bortezomib-Dexamethasone (CyBorD) withDaratumumab (DARA) in transplant eligible patientswith newly diagnosed Multiple Myeloma (MM). “TheCyBorD-DARA study” | Newly Diagnosed Multiple Myeloma |
Currently open and recruiting in Galway University Hospital and Cork University Hospital and Beaumont. The Mater will open in 2017 |
CyBorD-Dara |
GUH:PI: Professor Michael O’DwyerContact:Jessica Walsh +353 (0)91 893314 The Mater:PI: Professor Peter O’GormanContact: Martina Smith+353 (0)18 03 4838 Cork University Hospital:PI: Professor Mary CahillContact:Debra O’Hare+353 (0)21 49 20051 Beaumont:PI: Dr. John QuinnContact:Tara Kenny +353 (0)18 09 2080 St James:PI: Dr. Patrick Hayden+353 (0)14 16 2212 |
Acute Myeloid Leukemia
Study Title |
Patient Population |
BCNI Sites Open for Enrollment |
ClinicalTrials.gov link for further study info |
Study Contacts |
|---|---|---|---|---|
| A Phase I/II, Open-label Multicenter Trial to Determine Safety, Pharmacokinetics and Efficacy of GMI-1271 in Combination With Chemotherapy in Patients With Acute Myeloid Leukemia |
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Galway University Hospital | GMI1271-201 | GUH: Jessica Walsh +353 (0)91 893314 |
UPCOMING CLINICAL TRIALS
3 studies curently open and recruiting
No new trials planned for the moment
