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BCNI researchers discover strategy that may help to overcome Myeloma metastasis and chemoresistance
BCNI researchers based in Galway and their collaborators have published significant new findings in the journal "Leukemia".
The researchers have shown that Myeloma cells that express high levels of the E-selectin ligand give rise to a more aggressive disease and were more resistant to chemotherapy. They also found that relapsed patients had higher levels of E-selectin expressing cells.Significantly they went on to demonstrate that by using an E-selectin antogonist (GM1271) they could prevent the cells becoming resistant to chemotherapy.
This work work is important because it provides a rational for targeting E-selectin receptor/ligand interactions to overcome metastasis and chemoresistance in Multiple Myeloma.
Leukemia paper accepted article